MS2 - up through Class of 2019

First Year (Phase 1) Curriculum, please see the Curriculum Renewal website.

Second Year Curriculum (Up through Class of 2019)

Second year courses are taught on each of the nine IUSM campuses, with course sequence, structure, and instructional method tailored to best suit each site.

Campus-specific curricular information is available through the following links:


Statewide Course Objectives

MS2 Statewide educational equivalency is ensured through adherence to Course Equivalency Guidelines PDF icon, which includes statewide course objectives, standardized credit hour allocation, and common final course assessment. The statewide course objectives for courses in the foundational science MS2 curriculum can be found by clicking on the links below.

  • Evidence-Based Medicine & Biostatistics

    EBM-01: Apply basic statistical and probability concepts that underlie clinical practice and medical research. (MK5)

    EBM-02: Demonstrate understanding of basic clinical research study design and its impact on the validity of study results. (MK5)

    EBM-03: Critically appraise medical research and apply findings to resolve a clinical question. (PBLI3)

  • Introduction to Clinical Medicine II

    ICM2-01: Integrate basic science information into their growing clinical knowledge base, including fundamentals of disease processes with an emphasis on common conditions, basic and fundamental aspects of medical therapy and radiographic correlations. (MK3)

    ICM2-02: Perform a complete history and physical examination. (PC2)

    ICM2-03: Perform a focused history and physical examination. (PC2)

    ICM2-04: Generate a prioritized hypothesis driven differential diagnosis. (PC3)

    ICM2-05: Generate a prioritized problem list. (PC3)

    ICM2-06: Apply appropriate diagnostic tests to the differential diagnosis. (PC3)

    ICM2-07: Generate a treatment plan at a novice level. (PC3)

    ICM2-08: Effectively document a full history and physical examination. (ISC5)

    ICM2-09: Perform oral presentations of patient cases at a novice level. (ISC2)

    ICM2-10: Effectively communicate with patients in a respectful manner, establishing rapport and an effective physician patient relationship. (ISC5)

    ICM2-11: Develop a foundation of knowledge about electronic medical records (EMR) . (ISC5)

    ICM2-12: Document accurately in an EMR. (ISC5)

    ICM2-13: Synthesize information from an EMR. (ISC5)

    ICM2-14: Carry out professional responsibilities with the highest standards of excellence and integrity, consistent with the Honor Code and with adherence to ethical principles. (P2)

    ICM2-15: Recognize ethical issues in medical practice. Identify most relevant ethical considerations and employ ethical concepts and reasoning when presented with model cases in medicine .(P3)

    ICM2-16: Apply principles of ethics and professionalism to issues in healthcare delivery. (P4)

    ICM2-17: Evaluate the impact of demographics, socioeconomic status, and other biopsychosocial factors on health care utilization and health outcome at individual and population levels. (SBP3)

    ICM2-18: Demonstrate fundamental knowledge of major models of healthcare finance. (SBP4)

    ICM2-19: Describe the effects of regulation on health and healthcare delivery. (SBP4)

    ICM2-20: Explain how patient safety and healthcare quality are important in patient care using a virtual health system model. (SBP5)

    ICM2-21: Assess adherence to evidence-based healthcare guidelines. (SBP5)

    ICM2-22: Describe the roles and responsibilities of different members of the healthcare team. (SBP6)

    ICM2-23: Consider the impact of cost on treatment decisions. (SBP7)

    ICM2-24: Assess the validity of sources of information about issues in health care. (PBLI3)

  • Immunology

    I-01: Explain the overall structure, function, and regulation of the immune system. (MK1)

    I-02: Differentiate between the innate and adaptive immune mechanisms used for host defense, including the role of tissues, cells, and soluble mediators. (MK2)

    I-03: Demonstrate an understanding of the critical role of MHC and antigen processing and presentation in the adaptive immune response. (MK1)

    I-04: Differentiate between B and T cell development, the recognition of antigens, and the activation of these cells. (MK1)

    I-05: Identify and explain how different immune responses contribute to pathological processes, including allergy, hypersensitivities, autoimmunity, rejection of transplanted tissues and organs, and responses to cancer. (MK2)

    I-06: Describe the characteristics of congenital and acquired immunodeficiency disorders and the consequences for the immune system’s ability to fight infectious pathogens. (MK2)

    I-07: Illustrate the principles of immunization and discuss its role in disease prevention. (MK4)

    I-08: Identify gaps in personal knowledge of medical immunology, identify and evaluate resources to help close these gaps, and articulate the information to peers. (PBLI2)

  • Medical Genetics

    MG-01: Describe the nature of DNA variations or mutations and their clinical importance. (MK2)

    MG-02: Identify mechanisms of inheritance and pathogenesis in genetic disorders, including single-gene modes as well as more complex genetic etiologies and the impact of epigenetics. (MK2)

    MG-03: Interpret the molecular and biochemical mechanisms contributing to disease, including how the molecular and/or biochemical defect results in the mode of inheritance and may impact considerations for treatment. (MK2)

    MG-04: Use a family history to draw a pedigree and calculate disease risk for an individual based on a pedigree, population gene frequency, and other modifying factors. (MK6)

    MG-05: Describe the basic principles of cytogenetics, including the indications for requesting chromosome analysis, clinical findings in the most common chromosomal disorders, risks to offspring of carriers with chromosomal rearrangements, implications of chromosome rearrangements in cancer, and current and future methodologies. (MK2)

    MG-06: Describe the clinical indications for prenatal diagnosis, the screening methods used, and the possible sources of samples needed for analysis. (MK6)

    MG-07: Apply knowledge of molecular genetics to describe the principles, uses, and limitations of genetic testing technologies, including the implications of incidental findings. (MK4)

    MG-08: Explain the basic principles of genetic counseling and the role and application of genetics in personalized medicine. (MK4)

    MG-09: Recognize the cultural, familial, and socio-economic influences that may impact an individual’s decision to pursue genetic testing and his/her understanding and interpretation of illness and treatment decisions. (MK7)

    MG-10: Recognize and discuss the ethical and legal implications associated with obtaining and using family or individual/personal genetic information or genetically-related treatments in clinical medicine. (P3)

    MG-11: Communicate genetic information accurately in an understandable, non-directive manner. (ISC5)

    MG-12: Know how to obtain current and accurate information about scientific and clinical applications of genetics. (PBLI3)

  • Microbiology

    M-01: Describe the structure, physiology, and genetics of the major classes of infectious organisms associated with human diseases. (MK2)

    M-02: Differentiate among the major pathogens associated with gastrointestinal, respiratory, CNS, skin and soft tissue, bone, circulatory, and urogenital infections. (MK2)

    M-03: Illustrate how host defense mechanisms, diagnostic strategies, and therapeutic approaches differ among organ systems. (MK4)

    M-04: Explain the concepts of virulence and virulence factors, and apply this knowledge to the understanding of the pathogenesis of microbial diseases. (MK2)

    M-05: Explain the mechanisms of action of the major classes of antibiotics, anti-virals, anti-fungals, and anti-parasitic agents, including their use against specific pathogens, their effect on normal flora, adverse reactions, and the problem of drug resistance. (MK4)

    M-06: Categorize methods to prevent the spread of contagious organisms, including universal precautions, sterile techniques, sterilization, and disinfection, and apply these methods to the prevention of nosocomial infections. (MK4)

    M-07: Identify general microbiology laboratory techniques and explain how they are used to differentiate among microbial agents that cause human diseases. (MK3)

    M-08: Explain how issues of geography, economics, culture, vaccination, and public health affect patterns of infectious disease epidemiology and approaches to disease prevention. (MK7)

    M-09: Identify gaps in personal knowledge of medical microbiology, identify and evaluate resources to help close these gaps, and articulate the information to peers. (PBLI1)

  • Neuroscience

    NS-01: Describe the gross, histologic, and cellular structure of the central and peripheral nervous system. (MK1)

    NS-02: Describe the anatomy and physiology of the major functional systems of the nervous system (motor, sensory, homeostatic, emotional, memory, language, cognition, and consciousness) and the functional deficits and/or clinical presentations that result from lesions of each system. (MK1)

    NS-03: Describe the normal development of the nervous system and the basic mechanisms and clinical manifestations of common congenital anomalies. (MK1)

    NS-04: Localize lesions of the peripheral and central nervous system by recognizing patterns of neurologic deficits from the patient history and neurologic exam. (MK3)

    NS-05: Recognize the clinical presentations of major diseases of the nervous system. (MK3)

    NS-06: Describe how to perform and interpret a complete neurological exam. (MK3)

    NS-07: Demonstrate proficiency in the gathering, analysis, synthesis, and evaluation of new information that the student self-identifies as necessary to understand more completely the causes, effects and treatments of neurological problems. (PBLI2)

    NS-08: Demonstrate effective communication skills by the clear and concise articulation of ideas and by listening carefully to others. (ISC5)

  • Pathologic Basis of Disease

    PAT-01: Describe Pathology as a specialty and identify appropriate utilization of different pathologic tests to assist a clinician with diagnosis and management of disease. (SBP6)

    PAT-02: Explain the pathophysiologic basis of general cellular and tissue response to injury and disease. (MK1)

    PAT-03: Recognize and interpret gross, histologic, and molecular changes associated with general types of disease processes. (MK3)

    PAT-04: Describe and interpret the pathophysiologic changes which occur in the major disease processes associated with a given organ system of the human body including cardiovascular, digestive, endocrine, immune, integumentary, lymphatic, muscular, nervous, renal, reproductive, respiratory, and skeletal systems. (MK3)

    PAT-05: Demonstrate knowledge of disease processes by creating a differential diagnosis based on clinical history, physical examination findings, pathology testing, laboratory studies, and radiology and anticipating disease course. (MK3)

    PAT-06: Demonstrate the ability to communicate clinical, laboratory, radiographic, and pathologic findings and their clinical impression of a disease process in an effective manner. (ISC3)

  • Pharmacology

    PHA-01: Explain the fundamental principles of pharmacology, ie pharmacokinetics and pharmacodynamics. (MK4)

    PHA-02: Apply pharmacodynamic and pharmacokinetic principles employing physiology and biochemistry to explain drug action. (MK4)

    PHA-03: Delineate the mechanism of action, therapeutic indications, contraindications, major adverse effects, and drug-drug interactions of therapeutically significant drugs. (MK4)

    PHA-04: Apply pharmacologic therapies to counteract or ameliorate pathophysiologic mechanisms causing disease. (MK4)

    PHA-05: For any organ system, describe the classes of drugs that can affect function focusing on mechanism of action and whether these changes are beneficial or toxic. (MK4)

    PHA-06: Explain the basic principles of toxicology and how toxins alter normal clinical parameters. (MK2)

    PHA-07: Explore safety considerations that impact prescribing practices. (SBP5)

    PHA-08: Explore ethical considerations that impact prescribing. (P3)

    PHA-09: Recognize the student’s role in small group work particularly in terms of preparation and participation. (P2)

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